What’s Psilohuasca?

Psilohuasca resembles ayahuasca because it is a mixture of a psychedelic substance and an MAO-inhibitor. In the case of Ayahuasca it is the psychedelics DMT and in the case of psilohuasca it is the psychedelics psilocybin/psilocin. The differences between the action of DMT and psilocin are small since they excite receptors to about the same extent. However, there is a small difference in receptor profile that explains the differences.

The molecular difference between DMT and psilocin is only the OH group at the 4th position

Why the MAOIs?

The use of MAOIs in Ayahuasca makes sense. The enzyme MAO breaks down the active substance DMT immediately after ingestion. An MAO inhibitor or MAOi prevents that MAO DMT can break down. The MAO inhibitor also ensures that other Monoamines are not broken down such as dopamine and tyramine. Building up dopamine is in many cases not desired for therapy, but it is not a big problem either. However, building up tyramine is a problem. Tyramine can cause high blood pressure, brain haemorrhages and even death. In order to prevent the problems with tyramine, an adapted diet should be followed.

Read more about tyramine, MAO and the diet here.

Hazardous combinations with MAOIs

To indicate once again that the MAO inhibitors can cause dangers, we hereby provide a list of substances that are very dangerous in combination with MAO inhibitors. The following substances should not be used 24 hours before and 24 hours after the trip.

  • soporifics
  • anesthetics
  • migraine drugs
  • allergy medications
  • colds
  • cocaine
  • amphetamine (speed)
  • MDMA (XTC)
  • mescaline cacti (peyote and san pedro)
  • alcohol
  • ephedra/ephedrine
  • pseudoephedrine
  • macromerine
  • fentermine.

Can it be done without MAOIs?

The MAO inhibitors increase the risk of health complaints. Also, the build-up of dopamine more often results in a less good effect of psychedelics (according to our experience). Ayahuasca cannot do without MAOIs because otherwise DMT does not work orally. But Psilohuasca can do without MAOIs. Psilocybin and psilocin can be absorbed effortlessly and remain active for 4-6 hours. If you do add MAO inhibitors you can save on the amount of psilocybin containing magic mushrooms or truffles. If you add a lot of MAO inhibitors the trip will also take a few hours longer.

Why would you want to run the extra risk of complications?

We believe that the advantages of MAOIs do not outweigh the disadvantages. Saving on costs should not be the reason. Extending the duration of the trip can be an advantage and a disadvantage. A good intense trip doesn’t have to be super long. We prefer a high dose and then a good trip rather than a long mild trip.

Passion flower as MAO inhibitor

The passion flower is a mild MAO inhibitor and will enhance magic mushrooms or truffles and prolong the trip without many extra risks. The combination of psilocybin and the passion flower (passiflora incarnata) is also called psiloflora and is in our opinion the perfect combination of not the extra risks of a heavy MAO inhibitor, but the benefits of a light MAO inhibitor.

The Passiflora trip

The advantage of using the passion flower is that initially less mushroom or truffle is needed to achieve the same triple skin. Compared to other commonly used MAO inhibitors, the passion flower has a much milder effect and therefore the risks are lower (but take the regulations for safety seriously). The advantages of the passion flower are:

  • Soothing effect
  • Deeper trip (triplevel 5)
  • Longer trip (up to 8 hours)
  • Clear trip
  • More visual trip

Apart from the improving effect of a psychedelic trip the passiflora incarnata is also sometimes used without psychedelics against ADHD, nervousness, nervous heart problems, Parkinson’s disease, seizures, muscle cramps, hysteria, hypertension, PMS, epilepsy, skin disorders, hemorrhoids, burns, asthma, whooping cough, bronchitis, infections and as a painkiller for many ailments. Also for problems related to menopause. It is also used as a means to reduce the effects of alcoholism, to make it easier to stop drinking and is also used for delirium tremens.

Read more about passiflora incarnata here

More about the psilohuasca or psiloflora trip

You can experience the psiloflora trip through us. More information and booking this psychedelic trip including support can be found via the link:

Psilohuasca ceremony (psiloflora)